Abstract 4141423: Bridging the Divide: Evaluating Outcomes Between the Sexes for Transcatheter Aortic Valve Replacement

Introduction: Sex-related short-term outcomes following transcatheter aortic valve replacement (TAVR) are known. There is less data comparing the long-term differences in outcomes between sexes. Studies suggest women are less likely to be referred for TAVR and have higher mortality. This study investigated the differences between genders and races on outcomes in the following 6 and 12 months post-TAVR. Questions: Are there differences in outcomes between males and females who undergo TAVR? Are there differences in outcomes between females of different races undergoing TAVR? Methods: We performed a retrospective cohort study among 252 patients undergoing TAVR between 2018 and 2023 at a major academic medical center in Chicago, Illinois. Primary outcomes included composite major adverse cardiac events (MACE) (CVA, MI and/or CVA) and all-cause death. Outcomes were analyzed at 6 and 12 months following TAVR. T and Chi square tests were used to analyze continuous/categorical variables respectively. Results: Among the 252 patients studied, 27.4% were female, 27.5% white, 47.8% black, 10.1% Hispanic/Latino, 14.45% other. Average age of females and males were 77 ± 1 years and 75 ± 0.74 years (p=0.2967), respectively. Males were more likely to be former smokers (p=0.000) and to drink more than 8 alcoholic beverages per week (p=0.023). No significant differences were seen between genders for MACE, all-cause death, CVA or MI at 6 or 12 months (Table 1). There were also no significant differences were found between females of different races for MACE, all-cause death, CVA, or MI at 6 or 12 months. There was a significant difference by race for development of conduction abnormalities found at 6-month follow-up (p=0.02). Conclusion: This study shows females appeared to have similar outcomes at 6 and 12 months following TAVR when compared to males. However, the possible causes leading to increased development of conduction abnormalities found at 6 months follow up between female racial groups needs to be further studied.