Abstract 4140963: Major Adverse Cardiovascular Events in Patients with Chronic Atrial and Intestinal Dysrhythmia Syndrome: A Nationwide Analysis

Introduction: Chronic Atrial and Intestinal Dysrhythmia Syndrome (CAIDS) is a rare but intriguing pathology caused by simultaneous arrhythmias impacting both the cardiovascular and gastrointestinal systems. Due to the rarity of the condition, the research remains largely unexplored. As such, the primary focus of this study is to unravel cardiovascular risk within this syndrome. Hypothesis: Patients hospitalized with CAIDS experience a high burden of major adverse cardiovascular events (MACE). Aim: While there is no well-understood etiology for this condition, We aim to analyze data on MACE in patients with CAID to gain insight into their cardiovascular risk. Methods: We queried the National Inpatient Sample (NIS) between 2016 and 2020, searching for adult patients hospitalized for CAIDS using ICD-10 codes. The primary outcomes were MACE and inpatient mortality. Propensity scores were used to match patients with CAIDS who experienced MACE and those who did not. Multivariate and univariate logistic regressions were applied for outcomes, adjusting for age and gender. A p-value of <0.05 was considered significant. Stata 18 was used for analysis. Results: The mean age of the cohort experiencing CAIDS was 76.42 years (95% CI: 75.30-77.54), with a slightly higher proportion of males (63.64%) compared to females (36.36%). The average length of stay for patients with CAIDS was 8.37 days (95% CI: 7.60-9.14). The in-hospital mortality rate for patients with CAIDS was 3.39% (OR 1.02, p = 0.965, 95% CI: 0.51-2.00). Additionally, 3.12% of patients with CAIDS experienced cardiac arrest (OR 3.87, p < 0.001, 95% CI: 1.87-7.99). STEMI was observed in 1.30% of patients with CAIDS (OR 2.65, p = 0.068, 95% CI: 0.93-7.54). Cardiogenic shock was present in 0.52% of patients with CAIDS (OR 12.66, p < 0.05, 95% CI: 1.14-139.94). Heart failure occurred in 36.88% of patients with CAIDS (OR 4.16, p < 0.001, 95% CI: 3.09-5.60), and stroke was present in 10.65% (OR 2.89, p < 0.001, 95% CI: 1.96-4.26). Dilated Cardiomyopathy occurred in 5.2% (OR 5.7, p < 0.001, 95% CI: 3.06 -10.68) Conclusion: Patients with CAIDS face significant risks, with elevated rates of MACE such as cardiac arrest, cardiogenic shock, dilated cardiomyopathy, heart failure, and stroke, although STEMI and in-hospital mortality were not statistically significant.This underscores the critical importance of vigilance in monitoring and managing these patients to mitigate such outcomes.