Abstract 4141732: Small Left Ventricular Chamber Size and Mortality in a General Population

Background: Enlargement of the left ventricle (LV) is well recognized as an important marker of adverse cardiac remodeling and poor prognosis in the setting of known cardiovascular disease as well as in general populations. Previous studies demonstrated increased cardiovascular risk in small subsets of patients with small LV chamber size, however, the prognostic implications of small chamber size in a general population remains unclear. The objective of this study was to examine the prognosis of a small LV chamber in a large cohort of patients undergoing echocardiography. Methods: All consecutive subjects that underwent echocardiography examinations recorded in the echocardiography database of a university-affiliated laboratory from 2011 to 2023 were retrieved for analysis. Small chamber size was defined as end-diastolic diameter less than 42 mm for men and 37.8 mm for women as per ASE guidelines. The primary endpoint for the study was all-cause mortality. Results: 46,529 subjects (mean age 60 ± 19 yrs, 56% males) were included in the study of whom 3,787 had small LV chamber size. Clinical variables associated with small chamber included increasing age and lower BSA. Echocardiographic variables included higher relative wall thickness, and E:e' . On multivariate analysis, the presence of a small LV was significantly associated with mortality (HR 1.43 with 95% CI 1.33-1.54; p <0.001). This finding was significant in both older (over 65) (HR 1.30 95% CI 1.19-1.41; p <0.001) and younger (HR 2.09 95% CI 1.81-2.41; p <0.001) subjects and in both males and females. Conclusions: In this retrospective large cohort study, small LV chamber size was significantly associated with mortality in a broad range of patients. Further study is necessary to elucidate the mechanisms for this finding.