Formulation & Evaluation of Sustained Release Diclofenac Sodium Microspheres

The present work sought to explore the dissolution profile and release kinetics of modified release diclofenac sodium microspheres comprising sodium carboxy methyl cellulose, hydroxy propyl methyl cellulose (HPMC), and polyvinyl pyrrolidine (PVP K30). The impact of these polymers on drug release mechanism was investigated. The Ionic-gelation process was used to create nine formulations with varying quantities of polymers. The FT-IR technique was employed for analysing interactions among polymers and active medicinal molecules. Scanning electron microscopy was utilized to examine the produced microspheres' form and surface morphology. The average particle size was determined using optical microscopy. The produced microspheres ranged from 50-110 µm and were ideal for modified medication delivery. Moisture content, drug entrapment efficiency, and percent yield were measured for the prepared microspheres, and the findings were satisfactory. F3 created with a drug: polymer ratio of 1:3 and 3% sodium alginate in 4% calcium chloride shown up to 99% retarding effects during an invitro drug release testing. Statistical models revealed that the drug release mechanism followed the zero order kinetic model. Finally, it was determined that sodium carboxy methyl cellulose, hydroxy propyl methyl cellulose (HPMC), and polyvinyl pyrrolidine (PVP K30) were acceptable polymers for producing diclofenac sodium microspheres as a modified or sustained release drug delivery method. Key words: Diclofenac sodium, Ionic gelation, Sodium CMC, HPMC, PVP K30, Sustained release drug delivery, FT-IR, Scanning Electron Microscopy