Abstract 4144032: Decadal Trends in Heart Failure Prevalence (2013-2023) Among Women of Childbearing Age with Prior Adverse Pregnancy Outcomes: Insights from a Population-Based Study

Background: Heart failure (HF) represents a critical public health concern, especially among women of childbearing age, where its prevalence has been steadily increasing over recent years. Women with prior adverse pregnancy outcomes, such as hypertensive disorders of pregnancy, gestational diabetes mellitus, or preterm birth, face an elevated risk of developing heart failure later in life. Methods: This study investigated heart failure prevalence and trends over the period 2013 to 2023, leveraging data from 64 healthcare organizations within the TriNetX global health research network within the US Collaborative Network. The cohort consisted of 979,178 females aged 15-60 who had maternal care-related encounters and were diagnosed with specific conditions indicative of adverse pregnancy outcomes. These conditions included hypertensive disorders of pregnancy, gestational diabetes mellitus, placenta previa, intrauterine growth restriction, or macrosomia. Prevalence rates were calculated annually and stratified by age and race. The analysis encompassed January 1, 2013, to December 31, 2023, with a one-day lookback period. Results: Across the decade from 2013 to 2023, there was a notable surge in heart failure prevalence, escalating from 0.39% to 1.26%, corresponding to an average annual increase of approximately 12.38%. When examining racial disparities, Asians exhibited the lowest prevalence rates, initiating at 0.236% in 2013 and ascending to 0.673% in 2023, with an average annual increase of roughly 10.1%. Of note, the Black or African American cohort manifested the highest prevalence rates in both 2013 (0.708%) and 2023 (2.35%), with an average annual increase of approximately 12.77%. Within the 45-49 years age group, prevalence surged from 1.69% to 2.57%, signifying an average annual rise of about 4.36%, highlighting the escalating burden of heart failure among middle-aged adults. Conclusions: This study illuminates a concerning surge in heart failure prevalence over the past decade, revealing alarming rises across age and racial demographics. Particularly noteworthy is the heightened impact on younger individuals and certain minority groups, notably Black or African American patients.