Abstract 4144055: Adverse Physical Environment, Housing, and Economic Conditions: Their Impact on Maternal Cardiovascular Health during and Post-Pregnancy

Background: Maternal cardiovascular health is a critical concern, particularly during and following pregnancy. Previous studies have highlighted the influence of social determinants on health outcomes, but the specific impact of adverse Physical Environment, Housing, and Economic Conditions on maternal cardiovascular health remains underexplored. Methods: Using the TriNetX global health research network within the US Collaborative Network, we explored how adverse Physical Environment, Housing, and Economic Conditions (ICD10CM: Z58 and ICD10CM: Z59) impact maternal cardiovascular health during pregnancy and within one year postpartum. Using, propensity score matching (PSM) analysis, our study compared two cohorts: women aged 15 to 60 who experienced issues related to Physical Environment, Housing, and Economic Conditions during or after pregnancy from 2008 to 2023, and women in the same age range who did not face such issues, thus representing a favorable physical environment, housing, and economic conditions. Results: Challenges related to the physical environment, housing, and economic conditions significantly increased the risk of all-cause mortality (OR: 3.237, 95% CI: 2.064 to 5.075, p<0.001), acute myocardial infarction (MI) (OR: 2.831, 95% CI: 1.422 to 5.634, p=0.002), major adverse cardiac and cerebrovascular events (MACCE) (OR: 2.734, 95% CI: 1.953 to 3.782, p<0.001), and ischemic stroke (OR: 2.082, 95% CI: 1.074 to 4.037, p=0.026). On the other hand, no significant correlation was found between adverse physical environment, housing, and economic conditions and the incidence of peripartum or postpartum preeclampsia (OR: 0.994, 95% CI: 0.904 to 1.093, p=NS), peripartum or postpartum eclampsia (OR: 1.178, 95% CI: 0.852 to 1.629, p=NS), hemorrhagic stroke (OR: 1.202, 95% CI: 0.519 to 2.782, p=NS), or peripartum cardiomyopathy (OR: 0.977, 95% CI: 0.631 to 1.511, p=NS). Conclusion: Women exposed to adverse physical environment, housing, and economic conditions conditions experienced higher rates of cardiovascular problems compared to those in more favorable circumstances.