Abstract 4144907: Left ventricular-arterial coupling and mortality in the cardiac intensive care unit

Background: Ventricular-arterial coupling (VAC) refers to the ratio of afterload (effective arterial elastance) to contractility (left ventricular (LV) end-systolic elastance) as an integrated marker of cardiac performance. Echocardiography might be used to evaluate VAC through a simple time-efficient bedside evaluation. Hypothesis: VAC is useful for mortality risk stratification in an unselected cardiac intensive care unit (CICU) cohort. Aims: We sought to determine whether the VAC ratio, defined using the ratio of LV end-systolic volume (LVESV) to stroke volume (SV), predicted mortality in the CICU. Methods: Consecutive patients admitted to the Mayo Clinic CICU between 2007 and 2018 were included. The simplified VAC ratio was calculated as the LVESV calculated from 2D measurements using the Teichholz formula divided by the SV calculated from the LV outflow tract pulsed wave Doppler measurement, with values >1 reflecting ventricular-arterial uncoupling. The main outcome was all-cause in-hospital mortality. Results: We included 4685 patients with a median age of 69 (58-79) years; 37% were females. The median VAC ratio was 1.0 (0.7 to 1.8) and 21% of patients had a VAC ratio >2. Most clinical and echocardiographic variables differed in patients with higher VAC ratio, reflecting greater severity of illness with worse cardiac systolic and diastolic function. A total of 329 (7.0%) patients died during hospitalization. An incremental association was observed between a higher VAC and in-hospital mortality (unadjusted OR 1.22, 95% CI 1.16-1.29, p<0.001). Patients with a VAC ratio >1 (unadjusted OR 2.85, 95% CI 2.22-3.69, p <0.001) and especially those with VAC ratio >2 (unadjusted OR 4.28, 95% CI 3.24-5.69, p<0.001) had higher in-hospital mortality overall and in each admission diagnosis subgroup of interest ( Figure ). After multivariable adjustment, patients with a VAC ratio >2 remained at higher risk of in-hospital mortality (adjusted OR 1.63, 95% CI 1.17-2.28, p = 0.01). Conclusions: Ventricular-arterial uncoupling was associated with worse outcomes in an unselected CICU cohort. The echocardiographic VAC ratio is a simple non-invasive bedside measure that can be used for risk prediction in the CICU.