Nodal Metastasis in Endometrial Cancer Anticipated by Simple Pretreatment NLR and PLR Serum Marker

Background: Endometrial cancer is the sixth most common malignancy in females according to Globocon data 2020 and has been increasing in recent years. Advanced stage, type II sub type, deep myometrial invasion and lymph node (LN) metastasis are Prognostic factors. Radiological imaging such as MRI quite useful for the detection of disease extent, still MR had a 10% false positive rate and a 35% false negative rate. So Surgical staging becomes mandatory to stage the disease for apparently uterine confined endometrial cancer includes TAH + BSO + LN Assessment either with minimally invasive or open technique along with peritoneal fluid cytology. Material And Methods: This study was a prospective observational study which was conducted under Department of Surgical Oncology, Government Rajaji Hospital and Madurai Medical College, Madurai. Non metastatic endometrial cancer FIGO stage IA-III who underwent surgical staging were studied. Thus, total 50 patients were studied. The study was carried out for a period of November 2022 to September 2023. The collected data was compiled in Microsoft Excel 2010. Data describing quantitative measures was expressed as mean, median, mean + SD, standard deviation. Qualitative type of data was expressed as percentage or proportion. Data was analyzed using SPSS (Statistical Programme for Social Sciences) software 21 version, Open Epi Software Version 2.3. Results: A total of 50 patients were enrolled in this study (median age was 58 years, ranging from 30 to 75 years). Mean NLR was 3.5 + 0.8 and 2.1+0.3 in positive and negative cases of lymph node metastasis respectively. And mean PLR was 226.1 + 33.4 and 107.9+41.1 in positive and negative cases of lymph node metastasis respectively. Present study showed that LN metastasis was more frequently observed in patients with Type II tumor (p <0.001), Deep myometrial invasion (p =0.01), Cervical stromal invasion (p = 0.007), lymphovascular invasion (p<0.001), positive washing cytology, ..........