Bone mineral density in a sample of patients with type 1 and type2 diabetes mellitus

ABackground: Diabetes, whether type 1 or 2, is one of the world’s biggest health problems. The disease may affect all organ systems. The relationship between diabetes and bone mineral density (BMD) is a matter of debate.Aims: To assess the effect of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) on the bone mineral density in adult patients.Patients and Methods: This is a cross-sectional study which included a total of 25 patients with T1DM, 25 patients withT2DM and other 25 apparently healthy subjects. Bone mineral density was measured using densitometry. Serum calcium, phosphorus, alkaline phosphatase (ALP were measured spectrophotometrically.Results: hip BMD and spine BMD were higher in T2DM (1.24±0.19 g/m2, and 1.22±0.22 g/m2, respectively) than T1DM (0.94±0.78 g/m2 and 11.02±0.3 g/m2, respectively) with significant difference. In T1DM group, spine Z-score had a positive significant correlation with BMI (r= 0.882, p<0.001). In T2DM group, Spine Z-score also had significant positive correlation with each of weight (r= 0.913, p<0.001) and BMI (r= 0.952, p<0.001). Conclusions: Patients with T1DM have lower BMD in terms of spine and hip Z-score than patients with T2DM or healthy controls. Bone mineral density parameters positively correlate with body weight and BMI.Key word:bone mineral density in diabetes patients