Correlation between Serum Lipid profiles and Severity of Acne Vulgaris among Young Patients

Background: Acne vulgaris is one of the most presenting skin diseases that affecting late adolescents not only in Iraq, but also worldwide. As the skin is enriched in lipids, the disturbance of skin lipid arrangement was not only linked to development of acne, but also linked to development of atopic dermatitis and other skin conditionsAim: To establish the presence of lipid alteration in acne patients and its relation to the severity of acne.Methods: This is cross-sectional study to investigate the correlation between serum lipid profiles and severity of acne vulgaris among young patients conducted in the Department of Dermatology and Venereology in Al-Kindy Teaching Hospital, Baghdad, Iraq during a period from June 2019 to November 2020.Results: The mean age was 20.7 (± 2.1) years, with a minimum age of 15 years old, and a maximum of 24 years old. The males represented 55 (34.4%) with male to female ratio 1:2. Two third of them the BMI was above 25 kg/m2. In half of patients the socioeconomic status was fair and another half were good. There were 85 (53.1%) patients have dyslipidemia. The distribution of mean total cholesterol was significantly higher among overweight and obese patients (p value = 0.001). . While majority of patients (more than 80%) have dyslipidemia in severe and very severe group. There was a significant association between dyslipidemia and severity of acne (p value = <0.0001). There was significantly higher mean of total cholesterol and LDL among severe and very severe group in comparison to other groups (P value <0.0001). Also, There was significantly higher mean of TG among severe group in comparison to other group (P value <0.0001).Conclusion: The lipid profile alteration has a significant association with the severity of acne vulgaris. The cholesterol and LDL have the major impact.