Lipid-core nanocapsules containing simvastatin do not affect the biochemical and hematological indicators of toxicity in rats
Our research group previously studied the effectiveness of lipid-core nanocapsules (LNC) containing simvastatin (SV-LNC) in treating cognitive impairment in rats. While our results were promising, we needed to evaluate the potential toxicity of the nanoparticles themselves. This study aimed to compare the biochemical and hematological parameters of adult Wistar rats receiving LNC or SV-LNC to those receiving low doses of simvastatin crystals dispersed in a saline solution over 45 days. We discovered that LNC and SV-LNC, which are both nanometers in size with low polydispersity index, negative zeta potential, and high SV encapsulation efficacy, were not more toxic than SV crystals based on various biochemical markers of hepatic, pancreatic, renal, mineral, bony, alkaline phosphatase, glucose, and uric acid damage. Furthermore, LNC exhibited no toxicity for hematological parameters, including red and white blood cell counts. Based on this animal model of toxicological study, our findings suggest that long-term administration of LNC is a safe and promising nanocarrier.
Authors
- Oswaldo Luiz Alves (ORCID: https://orcid.org/0000-0002-1518-2092)
- Nathana J. Mezzomo (ORCID: https://orcid.org/0000-0001-7855-4343)
- S. Davies (ORCID: https://orcid.org/0000-0001-5457-5852)
- Rodrigo de Almeida Vaucher (ORCID: https://orcid.org/0000-0002-8306-9243)
- Isabel Roggia (ORCID: https://orcid.org/0000-0002-1901-6390)
- Virgínia Cielo Rech (ORCID: https://orcid.org/0000-0003-1330-8031)
- Renata Platcheck Raffin (ORCID: https://orcid.org/0000-0001-6432-9997)
- Graciela Schneider Vitalis (ORCID: https://orcid.org/0000-0001-9470-8883)
- Leticia Malgarim Cordenonsi (ORCID: https://orcid.org/0000-0002-3488-9878)
- José Alcides da Silva Viçosa
- Patrícia Gomes (ORCID: https://orcid.org/0000-0002-8020-6636)
- Ricardo Lorenzoni (ORCID: https://orcid.org/0000-0002-1432-639X)
- Amanda Lima de Oliveira (ORCID: https://orcid.org/0000-0002-7179-2450)
- Guilherme Machado do Carmo (ORCID: https://orcid.org/0000-0001-6757-0209)
Institutions
- Franciscan University of Steubenville (US)
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Pelotas (BR)
- Universidade Estadual de Campinas (UNICAMP) (BR)
- Universidade Franciscana (BR)
- Universidade Federal de Santa Maria (BR)
- Exact Sciences (United States) (US)
Publication Details
- Journal
- Toxicology Research
- Published
- 2024-11-05
- DOI
- https://doi.org/10.1093/toxres/tfae189
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul