Development of a protocol for whole-lung in vivo lung perfusion-assisted photodynamic therapy using a porcine model
We lay the groundwork for personalized preoperative <i>in silico</i> dosimetry planning to achieve desired treatment volumes within the therapeutic range. Chlorin e6 demonstrated the greatest therapeutic potential, with a minimal uptake in healthy lung tissues.
Authors
- Lothar Lilge (ORCID: https://orcid.org/0000-0001-5533-0005)
- Edson Brambate
- Vanderlei Salvador Bagnato (ORCID: https://orcid.org/0000-0003-4833-239X)
- Tina Saeidi
- Khaled Ramadan (ORCID: https://orcid.org/0000-0002-7042-8980)
- Marcelo Cypel (ORCID: https://orcid.org/0000-0001-5652-1938)
Institutions
- University Health Network (CA)
- University of Toronto (CA)
- Toronto General Hospital (CA)
- Princess Margaret Cancer Centre (CA)
- Texas A&M University (US)
Publication Details
- Journal
- Journal of Biomedical Optics
- Published
- 2024-11-15
- DOI
- https://doi.org/10.1117/1.jbo.29.11.118001
- Citations
- 1
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.42
Funders
- Princess Margaret Cancer Foundation
- Ontario Ministry of Health and Long-Term Care
- University of Toronto
- Ministero dello Sviluppo Economico