Molecular imaging of macrophage composition and dynamics in MASLD
Macrophage-mediated inflammation contributes to MASH progression and fibrosis; however, liver biopsy is currently the only tool to assess this response. Thus, the development of non-invasive imaging modalities to identify and follow inflammatory activation is an area of need for patient care. In this study, we leverage molecular imaging using PET radiotracers to follow changes in macrophage composition that are related to MASH disease activity. The results in our preclinical model provide important proof of concept evidence that this approach can be used to diagnose MASH and to follow disease activity in response to intervention. Ongoing studies will evaluate the utility of this modality in humans with MASH.
Authors
- Kathleen Byrnes (ORCID: https://orcid.org/0000-0002-9361-1120)
- Hannah Luehmann (ORCID: https://orcid.org/0000-0002-7516-6772)
- Alexandria Li
- Deborah Sultan
- Lanlan Lou (ORCID: https://orcid.org/0000-0003-4839-7708)
- Christopher Park
- Mandy M. Chan (ORCID: https://orcid.org/0000-0001-6511-0962)
- Christina Fu (ORCID: https://orcid.org/0000-0001-5555-3874)
- Joel D. Schilling (ORCID: https://orcid.org/0000-0002-3884-1994)
- Gyu Seong Heo (ORCID: https://orcid.org/0000-0001-6200-4742)
- Divangana Lahad
- Yongjian Liu (ORCID: https://orcid.org/0000-0002-1118-1535)
- Bin Yang (ORCID: https://orcid.org/0000-0002-9653-145X)
- Peter Voller
Institutions
- Washington University in St. Louis (US)
Publication Details
- Journal
- JHEP Reports
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1016/j.jhepr.2024.101220
- Citations
- 7
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Science Foundation
- Alvin J. Siteman Cancer Center
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Biomedical Imaging and Bioengineering