HNF4α-CDKL3 axis restricts MASLD progression by targeting FoxO1 via noncanonical phosphorylation
We unearthed an alternative but critical regulatory path of FoxO1 by the HNF4α-CDKL3 axis. CDKL3 serves as a guardian against MASLD and also may function as a prognosis indicator of FoxO1 inhibitor in MASLD treatment.
Authors
- Yanli Cao (ORCID: https://orcid.org/0000-0002-5739-4376)
- Pu Zhao (ORCID: https://orcid.org/0000-0001-6164-8300)
- Qiang Wang (ORCID: https://orcid.org/0000-0002-8735-8771)
- Qianqian Zheng (ORCID: https://orcid.org/0000-0001-5906-148X)
- Zhongqiu Pang
- Xuexin Li (ORCID: https://orcid.org/0000-0001-5824-9720)
- Shaoqin Zheng (ORCID: https://orcid.org/0000-0002-3027-7305)
- Ren Sheng (ORCID: https://orcid.org/0000-0002-2293-8986)
- Zexu Li (ORCID: https://orcid.org/0000-0002-4685-4656)
- Liu Cao (ORCID: https://orcid.org/0000-0001-6471-1993)
- Hui Zhang (ORCID: https://orcid.org/0009-0000-7666-3052)
- Chang Liu (ORCID: https://orcid.org/0000-0002-7867-6807)
- Yi Chen (ORCID: https://orcid.org/0000-0002-2310-1416)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-8865-0045)
- Qing Han
- Xun Sun (ORCID: https://orcid.org/0000-0001-5152-657X)
- Xueling Yang (ORCID: https://orcid.org/0000-0001-7239-4297)
Institutions
- Columbia University Irving Medical Center (US)
- Karolinska Institutet (SE)
- Fourth Affiliated Hospital of China Medical University (CN)
- First Hospital of China Medical University (CN)
- Columbia University (US)
- South China University of Technology (CN)
- China Medical University (CN)
- Guangzhou Medical University (CN)
- Northeastern University (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1097/hep.0000000000001147
- Citations
- 8
- Primary Topic
- FOXO transcription factor regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87