Gadoxetic Acid-Enhanced Magnetic Resonance Imaging Features Can Predict Immune-Excluded Phenotype of Hepatocellular Carcinoma
HCCs with rim APHE, peritumoral enhancement in arterial phase, and intermediate intensity on HBP with visual 3-point scale could be non-invasive biomarkers to predict the immune-excluded phenotype with the tumor immune barrier. These HCCs were most likely to respond to combined immunotherapy.
Authors
- Takamichi Murakami (ORCID: https://orcid.org/0000-0001-7782-548X)
- Masato Komatsu (ORCID: https://orcid.org/0000-0003-2007-0252)
- Takahiro Kodama (ORCID: https://orcid.org/0000-0002-6250-1324)
- Eisuke Ueshima (ORCID: https://orcid.org/0000-0001-8802-8793)
- Tetsuo Takehara (ORCID: https://orcid.org/0000-0001-5036-3457)
- Masatoshi Hori (ORCID: https://orcid.org/0000-0002-2523-3789)
- Takumi Fukumoto (ORCID: https://orcid.org/0000-0003-1592-4524)
- Nobuaki Ishihara
- Shohei Komatsu (ORCID: https://orcid.org/0000-0001-9059-2473)
- Takeru Yamaguchi (ORCID: https://orcid.org/0000-0002-4368-4882)
- Keitaro Sofue (ORCID: https://orcid.org/0000-0001-6132-1623)
- Akihiro Umeno
- Shuhei Yamamoto (ORCID: https://orcid.org/0009-0001-1003-9107)
Institutions
- Kobe University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Liver Cancer
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1159/000542099
- Citations
- 8
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.96
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science