Clinical Subtype Trajectories in Sepsis Patients Admitted to the ICU: A Secondary Analysis of an Observational Study
In two large cohorts, subtype change to δ was associated with worse clinical outcome and more aberrant biomarkers reflecting inflammation, coagulation, and endothelial dysfunction. These findings underscore the importance of monitoring sepsis subtypes and their linked host responses for improved prognostication and personalized treatment strategies.
Authors
- Marleen A. Slim (ORCID: https://orcid.org/0000-0002-6281-040X)
- Rombout B. E. van Amstel (ORCID: https://orcid.org/0000-0001-9296-8518)
- W. Joost Wiersinga (ORCID: https://orcid.org/0000-0003-2277-1343)
- Tom van der Poll (ORCID: https://orcid.org/0000-0002-9199-5079)
- Christopher Seymour (ORCID: https://orcid.org/0000-0001-8330-8489)
- Lonneke A. van Vught (ORCID: https://orcid.org/0000-0002-0152-3044)
- Alexander P. J. Vlaar (ORCID: https://orcid.org/0000-0002-3453-7186)
- Olaf L. Cremer (ORCID: https://orcid.org/0000-0003-4264-1108)
- Marcella C.A. Müller (ORCID: https://orcid.org/0000-0002-5309-179X)
Institutions
- University of Pittsburgh (US)
- University Medical Center Utrecht (NL)
- Amsterdam University Medical Centers (NL)
- Institute of Infection and Immunity (CA)
- University of Amsterdam (NL)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1097/cce.0000000000001176
- Citations
- 7
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- University of Pittsburgh
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Center for Translational Molecular Medicine
- National Institutes of Health