Human CFTR deficient iPSC-macrophages reveal impaired functional and transcriptomic response upon Pseudomonas aeruginosa infection
In summary, we present a defective phenotype in iMac<sup>ΔF508</sup> upon <i>P. aeruginosa</i> infection, which will constitute an ideal platform to further study the role of macrophages in the context of CF.
Authors
- Antje Munder (ORCID: https://orcid.org/0000-0002-3198-8336)
- David Tschritter
- Nico Lachmann (ORCID: https://orcid.org/0000-0002-4245-1497)
- Sylvia Merkert (ORCID: https://orcid.org/0000-0001-7275-4205)
- Burkhard Tümmler (ORCID: https://orcid.org/0000-0002-2566-8758)
- Débora Basílio-Queirós (ORCID: https://orcid.org/0000-0001-5745-0211)
- Anna‐Lena Neehus (ORCID: https://orcid.org/0000-0002-8573-6820)
- Jacinta Bustamante (ORCID: https://orcid.org/0000-0002-3439-2482)
- Jan Hegermann (ORCID: https://orcid.org/0000-0001-7893-8507)
- Manuel Nietert (ORCID: https://orcid.org/0000-0001-5443-7943)
- Ulrich Martin (ORCID: https://orcid.org/0000-0003-1058-4540)
- Matthias Mörgelin
- Claudio Rodriguez Gonzalez
- Sinem Ünal (ORCID: https://orcid.org/0009-0002-5460-5948)
Institutions
- Broad Institute (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Inserm (FR)
- Université Paris Cité (FR)
- Medizinische Hochschule Hannover (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Fraunhofer Institute for Toxicology and Experimental Medicine (DE)
- Universitätsmedizin Göttingen (DE)
- Dana-Farber Cancer Institute (US)
- German Center for Lung Research (DE)
- Institut des Maladies Génétiques Imagine (FR)
- Rockefeller University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fimmu.2024.1397886
- Citations
- 2
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Medizinischen Hochschule Hannover