Preclinical delayed toxicity studies of BCMA CAR T-cell injection in B-NDG mice with multiple myeloma
The present study demonstrated a low toxicity of BCMA CAR T-cell injection, with manageable side effects and good anticancer activity and without observable adverse effects. This study provides data to support future clinical studies of BCMA CAR T-cell injection for MM.
Authors
- Yuying Wen
- Jinlong Dai
- Cailing Dai
- Jianmin Guo (ORCID: https://orcid.org/0000-0003-3319-5580)
- Shuren Zhang (ORCID: https://orcid.org/0000-0002-1530-298X)
- Chun Liang (ORCID: https://orcid.org/0000-0002-1851-2130)
- Hongjian Li (ORCID: https://orcid.org/0000-0001-8467-638X)
- Wei Yang (ORCID: https://orcid.org/0000-0001-8402-0591)
- Qiqi Wu
- Jishuai Zhang
Institutions
- Guilin Medical University (CN)
- Hong Kong University of Science and Technology (HK)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fimmu.2024.1435934
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- Guangdong Academy of Sciences