Autoantibodies targeting interferons and GM-CSF are associated with adverse outcome risk, comorbidities, and pathogen in community-acquired pneumonia
In men with CAP, various c-aAb-including type 1 IFN and GM-CSF c-aAb-were associated with adverse clinical events and comorbidities, whereas c-aAb targeting an autoinflammatory cytokine were associated with a positive outcome in women. This suggests that the potentially immunomodulatory effects of c-aAb depend on pathogen, autoantibody specificity, comorbidity, and sex.
Authors
- Maria Hein Hegelund (ORCID: https://orcid.org/0000-0001-6287-1619)
- Camilla Koch Ryrsø (ORCID: https://orcid.org/0000-0002-8059-7331)
- Daniel Faurholt‐Jepsen (ORCID: https://orcid.org/0000-0001-8561-0155)
- Rikke Krogh‐Madsen (ORCID: https://orcid.org/0000-0003-4914-2715)
- Arnold Matovu Dungu
- Jakob Hjorth von Stemann (ORCID: https://orcid.org/0000-0002-4591-3052)
- Birgitte Lindegaard (ORCID: https://orcid.org/0000-0002-5236-8427)
- Sisse Rye Ostrowski (ORCID: https://orcid.org/0000-0001-5288-3851)
- M Laguarda
- Morten Bagge Hansen (ORCID: https://orcid.org/0000-0001-7257-9451)
Institutions
- University of Copenhagen (DK)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Zealand University Hospital (DK)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fimmu.2024.1459616
- Citations
- 2
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 0.77