Revealing the potential therapeutic mechanism of Lonicerae Japonicae Flos in Alzheimer’s disease: a computational biology approach
Through a comprehensive analysis, this study revealed that six core targets (MAPK8, CTNNB1, NFKB1, EGFR, BCL2, and NFE2L2) and six practical components (lignan, β-carotene, β-sitosterol, hederagenin, berberine, and baicalein) were involved in the mechanism of action of LJF against AD. Our work demonstrated that LJF effectively treats AD through its multi-component and multi-target properties. The findings of this study will establish a theoretical basis for the expanded application of LJF in AD treatment and, hopefully, can guide more advanced experimental research in the future.
Authors
- Xiang Yu (ORCID: https://orcid.org/0000-0003-1225-7666)
- Yao Liu (ORCID: https://orcid.org/0000-0002-1146-2804)
- Binsheng He (ORCID: https://orcid.org/0000-0002-2232-4634)
- Qi He (ORCID: https://orcid.org/0000-0002-0427-6210)
- Jianming Li (ORCID: https://orcid.org/0000-0002-5012-0989)
- Liang Tang (ORCID: https://orcid.org/0000-0001-9571-2323)
- Xiang Qin (ORCID: https://orcid.org/0000-0003-1524-027X)
- Xiaopeng Cheng (ORCID: https://orcid.org/0000-0001-5650-6770)
Institutions
- Changsha Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fmed.2024.1468561
- Citations
- 31
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province