Risk of dementia associated with anticholinergic drugs for overactive bladder in adults aged ≥55 years: nested case-control study
Of the different anticholinergic drugs used to treat an overactive bladder, oxybutynin hydrochloride, solifenacin succinate, and tolterodine tartrate were found to be most strongly associated with the risk of dementia in older adults. This finding emphasises the need for clinicians to take into account the possible long term risks and consequences of the available treatment options for an overactive bladder in older adults, and to consider prescribing alternative treatments that might be associated with a lower risk of dementia.
Authors
- Darren Mark Ashcroft (ORCID: https://orcid.org/0000-0002-2958-915X)
- Anthony Avery (ORCID: https://orcid.org/0000-0001-7591-4438)
- Martin Orrell (ORCID: https://orcid.org/0000-0002-1169-3530)
- Tom Dening (ORCID: https://orcid.org/0000-0003-3387-4241)
- Barbara Iyen (ORCID: https://orcid.org/0000-0001-9720-1180)
- Delia Bishara (ORCID: https://orcid.org/0000-0002-6254-2054)
- Brian Bell (ORCID: https://orcid.org/0000-0001-8577-7430)
- Carol Coupland (ORCID: https://orcid.org/0000-0002-2327-3306)
Institutions
- University of Nottingham (GB)
- King's College London (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- National Institute for Health and Care Research (GB)
- Institute of Mental Health (GB)
- NIHR Manchester Biomedical Research Centre (GB)
Publication Details
- Journal
- BMJ Medicine
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1136/bmjmed-2023-000799
- Citations
- 15
- Primary Topic
- Pelvic floor disorders treatments
- Type
- article
- Field-Weighted Citation Impact
- 7.05
Funders
- National Institute for Health and Care Research
- Department of Health and Social Care
- NIHR School for Primary Care Research