CAF-macrophage crosstalk in tumour microenvironments governs the response to immune checkpoint blockade in gastric cancer peritoneal metastases
Our findings provide a new molecular portrait of cell compositions associated with ICB resistance in patients with GCPM and aid in the prioritisation of therapeutic candidates to potentiate immunotherapy.
Authors
- Kai Yu (ORCID: https://orcid.org/0000-0002-2561-8160)
- Yuhong Xu (ORCID: https://orcid.org/0000-0001-5302-6392)
- Zexian Liu (ORCID: https://orcid.org/0000-0001-9698-0610)
- Junquan Chen (ORCID: https://orcid.org/0000-0002-4353-9327)
- Zhao-Lei Zeng (ORCID: https://orcid.org/0000-0003-4420-5625)
- Yongqiang Zheng (ORCID: https://orcid.org/0000-0003-3246-2800)
- Shuqiang Yuan (ORCID: https://orcid.org/0000-0003-3661-5069)
- Qi‐Nian Wu (ORCID: https://orcid.org/0000-0002-9771-9956)
- Run‐Cong Nie (ORCID: https://orcid.org/0000-0003-3595-6304)
- Wei Wei (ORCID: https://orcid.org/0009-0001-2870-2982)
- Hui Luo (ORCID: https://orcid.org/0000-0001-6312-9299)
- Yi‐Qian Pan (ORCID: https://orcid.org/0009-0003-2516-2778)
- Yuanfang Li (ORCID: https://orcid.org/0000-0003-1762-2634)
- Chengcai Liang (ORCID: https://orcid.org/0000-0001-7625-4574)
- Zhijun Zuo
- Qihua Zhang (ORCID: https://orcid.org/0000-0002-0707-2299)
- Yashang Zheng
- Bai-Wei Zhao
- Jiaqian Huang
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Gut
- Published
- 2024-11-12
- DOI
- https://doi.org/10.1136/gutjnl-2024-333617
- Citations
- 92
- Primary Topic
- Gastrointestinal Tumor Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 42.68
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- National Key Research and Development Program of China
- Science and Technology Planning Project of Guangdong Province
- Guangdong Special Support Plan
- Basic and Applied Basic Research Foundation of Guangdong Province