(+)-Borneol inhibits neuroinflammation and M1 phenotype polarization of microglia in epileptogenesis through the TLR4-NFκB signaling pathway
(+)-borneol inhibits microglial neuroinflammation and M1 phenotype polarization through TLR4-NFκB signaling pathway and reduces neuronal damage and apoptosis in SE mice. Therefore, (+)-borneol may be a potential drug for epilepsy modification therapy.
Authors
- Fankai Gao
- Yucai Ye (ORCID: https://orcid.org/0009-0004-4934-6237)
- Rulin Mi
- Shuo Li (ORCID: https://orcid.org/0000-0003-2331-2448)
- Zhaojun Wang (ORCID: https://orcid.org/0000-0003-2853-1850)
- Guofang Xue (ORCID: https://orcid.org/0000-0001-9235-5236)
- Alhamdu Adamu
Institutions
- Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fnins.2024.1497102
- Citations
- 8
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.98
Funders
- Shanxi Scholarship Council of China