Treatment with tofacitinib attenuates muscle loss through myogenin activation in the collagen-induced arthritis
Tofacitinib attenuated muscle loss in arthritic mice, increased muscle weight and muscle CSA. Activation of satellite cell regeneration, based on the increased expression of myogenin, is a potential mechanism involved in tofacitinib action against muscle loss.
Authors
- Thais Karnopp
- Rafaela Cavalheiro do Espírito Santo (ORCID: https://orcid.org/0000-0002-5518-3479)
- Sofia Loch
- Maria Luísa Gasparini
- Bárbara Jonson Bartikoski (ORCID: https://orcid.org/0000-0003-3032-4738)
- Thales Hein da Rosa (ORCID: https://orcid.org/0000-0002-0102-0471)
- Gustavo Flores Chapacais (ORCID: https://orcid.org/0000-0002-4676-3834)
- Leonardo Peterson dos Santos (ORCID: https://orcid.org/0000-0001-8623-5596)
- Renata Ternus Pedó
- Jordana Miranda de Souza Silva (ORCID: https://orcid.org/0000-0002-0357-4638)
- Andressa Di Domenico
- Mirian Farinon
- Ricardo Machado Xavier (ORCID: https://orcid.org/0000-0001-6570-4533)
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Klaipėda University (LT)
- Hospital de Clínicas de Porto Alegre (BR)
- Hospital de Clínicas (UY)
Publication Details
- Journal
- Advances in Rheumatology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s42358-024-00416-5
- Citations
- 1
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- Pfizer
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Hospital de Clínicas de Porto Alegre