Ectopic adrenocorticotrophic hormone syndrome in a 10-year-old girl with a thymic neuroendocrine tumor: a case report
This case presents some unique challenges related to the diagnosis, management, and treatment of thymic neuroendocrine tumor in a child. We can conclude that ketoconazole treatment was effective in managing hypercortisolemia in our patient. Further, a combination of functional imaging studies can be a useful tool in locating the source of ectopic ACTH secretion. Lastly, in cases of discrepancy in the results of stimulation tests, bilateral inferior petrosal sinus sampling is highly recommended to differentiate between Cushing disease and ectopic ACTH syndrome.
Authors
- David Zogala (ORCID: https://orcid.org/0000-0003-3372-1667)
- Michal Kršek (ORCID: https://orcid.org/0000-0002-5941-3489)
- Irena Aldhoon-Hainerová (ORCID: https://orcid.org/0000-0001-9783-9256)
- Mikuláš Kosák (ORCID: https://orcid.org/0000-0001-5947-5340)
- Karel Pacák
Institutions
- Charles University (CZ)
- Military University Hospital Prague (CZ)
- Thomayer University Hospital (CZ)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
- University Hospital Kralovske Vinohrady (CZ)
Publication Details
- Journal
- BMC Endocrine Disorders
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1186/s12902-024-01756-5
- Citations
- 2
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- Univerzita Karlova v Praze