Association of colon adenocarcinoma with SNPs variation of 3-untransulated region of Interlukin-23 Receptor

Colorectal cancer is most common cancer type recorded in high incidence in last decade in Iraq. Many factor have implicated in disease progressing and development, some un translated regions implicated indirectly with disease. The current study aims to detect the UTR of IL-23 receptor variations with some adenocarcinoma histological features. A case control study was implemented using PCR-sequencing of UTR of IL-23 receptor gene. Three SNPs were targeting in current study including (rs185937924 A>G, rs1653126126G>C and rs1300405558 T>A). The results showed deletion mutation observed in these SNPs, there were non-significant increases in deletion mutation in patients than control group (P=0.0983). The first SNP rs185937924 A>G shows non-significant association with adenocarcinoma (P= 0.247) for AA genotype and for AG and GG genotypes (P= 0.7353). A new allele was recorded in current study for rs1653126126 (G>A), non-significantly associated with disease in all genotyping for AG (P=0.3588). For AA (P=0.4049), a new allele also was observed in rs1300405558 (T>G), the genotyping showed non-significant association with disease TG (P=0.5554), TT (P=0.5288) and GG (P=0.5552). The target SNPs genotyping did not associate with well or moderate differentiation, target SNPs did not show significant relations with tumor staging and T. It can be concluded that the IL-23 receptor variation in adenocarcinoma has a new allele in study population (case and control) in the rs1653126126G>C (G>A) and rs1300405558 TA (TG). The new alleles did not associate with adenocarcinoma and with the histological features.