Quantitative proteomics analysis reveals the pathogenesis of obstructed defecation syndrome caused by abnormal expression of dystrophin
Decreased DMD expression in intestinal smooth muscle may upregulate L-type voltage-gated calcium channel expression, leading to excessive calcium influx which may cause a decrease in rectal propulsion, thereby contributing to the pathogenesis of ODS.
Authors
- Tiankun Wang (ORCID: https://orcid.org/0000-0001-9378-5422)
- Jingjing Tong (ORCID: https://orcid.org/0000-0001-8805-3278)
- Songlin Wan
- Luyao Li (ORCID: https://orcid.org/0000-0002-0250-8428)
- Qun Qian (ORCID: https://orcid.org/0000-0002-3701-3759)
- Meng Xu (ORCID: https://orcid.org/0000-0002-2218-6737)
- Congqing Jiang (ORCID: https://orcid.org/0000-0001-6324-5740)
- Yu Xiong
- Wenzhe Li
- Yanyan Chen (ORCID: https://orcid.org/0000-0001-5268-5265)
- Weicheng Liu (ORCID: https://orcid.org/0000-0003-1664-8728)
Institutions
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
Publication Details
- Journal
- World Journal of Gastroenterology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3748/wjg.v30.i45.4817
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00