PKMζ, a Brain-specific PKCζ Isoform, is Required for Glycolysis and Myofibroblastic Activation of Hepatic Stellate Cells
Because HSCs are also a major contributor of liver fibrosis, our data highlight PKMζ and VASP as targets to inhibit metabolic reprogramming, HSC activation, liver fibrosis, and the pro-metastatic microenvironment of the liver.
Authors
- Ningling Kang (ORCID: https://orcid.org/0000-0002-4565-7976)
- Aurpita Shaha (ORCID: https://orcid.org/0000-0001-5681-903X)
- Lianping He (ORCID: https://orcid.org/0000-0002-9627-5599)
- Tian Wang (ORCID: https://orcid.org/0000-0003-4295-5908)
- Xianghu Wang (ORCID: https://orcid.org/0000-0001-5515-0514)
- Bing Bai (ORCID: https://orcid.org/0000-0002-4082-1562)
- Yuanguo Wang (ORCID: https://orcid.org/0000-0003-4752-9908)
- Gaspar J. Kitange
- Wenming Bao
Institutions
- Anhui University of Science and Technology (CN)
- Hormel (United States) (US)
- Taizhou University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101429
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- National Institutes of Health
- Division of Cancer Epidemiology and Genetics, National Cancer Institute