A decade later: Assessing pregnant women's perspectives on non-invasive prenatal testing (NIPT) in Saudi Arabia

Since its introduction a decade ago, non-invasive prenatal testing (NIPT) has been recognized as a highly accurate and safe screening option for expecting mothers, with its efficacy hinging on awareness, perceptions, and understanding of the test. We surveyed pregnant women in Saudi Arabia between December 2023 and February 2024 to assess the knowledge and acceptability of NIPT among them. A total of 212 pregnant women from various risk levels, socioeconomic statuses, and trimesters participated in the study, which was carried out at King Saud University Medical City (KSUMC) via online forms. This study investigated factors affecting attitudes towards NIPT, including financial burden. Data were analyzed with descriptive statistics and chi-square tests to assess correlations. The survey revealed a significant lack of awareness about NIPT, with 64.6 % of participants unfamiliar with the test and 93.3 % answering knowledge-related questions incorrectly. Although 74.1 % were willing to undergo NIPT if it were free, only 30 % were willing to pay 1500 SAR (400 USD). These findings underscore the need for targeted knowledge translation efforts to enhance awareness and understanding of NIPT among pregnant women, highlighting the importance of addressing financial barriers and increasing educational outreach. Further research and interventions are needed to promote the uptake of NIPT and enhance the quality of antenatal care programs in Saudi Arabia.