Synthesis of phosphinic structural analogue of Met-Glu-His-Phe
The synthesis of a phosphinic structural analogue of the tetrapeptide Met-Glu-γ-His-Phe by adding the dipeptide component His-Phe to the adamantyl ester of the phosphinic pseudo-Met-[P]-Glu-peptide in the form of cyclic glutamate anhydride is proposed. The conditions for the interaction of phosphinic pseudo-Met-[P]-Glu-anhydride with His-Phe in free form to form phosphinic Met-[P]-Glu-γ-His-Phe tetrapeptide have been found. A chromatographic mass-spectrometry study, including MS2, and NMR of the phosphinic tetrapeptide on 1H, 13C, 31P nuclei was carried out using the methods of two-dimensional 1H–1H COSY, 1H–13C HSQC and 1H–13C HMBC NMR spectroscopy.
Authors
- И. П. Калашникова
- A. Ivanov (ORCID: https://orcid.org/0009-0006-2704-9906)
- Alexey V. Borodachev (ORCID: https://orcid.org/0000-0002-3458-5129)
- К. В. Шевченко (ORCID: https://orcid.org/0000-0003-1665-3236)
- N. F. Myasoedov (ORCID: https://orcid.org/0000-0003-1294-102X)
- I. Yu. Nagaev (ORCID: https://orcid.org/0000-0001-9301-103X)
- М. E. Dmitriev (ORCID: https://orcid.org/0000-0001-8870-195X)
- В. В. Рагулин (ORCID: https://orcid.org/0000-0002-3967-1034)
- В. П. Шевченко
Institutions
- Kurchatov Institute (RU)
- Moscow University «Synergy» (RU)
- Institute of Problems of Chemical Physics (RU)
Publication Details
- Journal
- Журнал Общей Химии
- Published
- 2024-10-14
- DOI
- https://doi.org/10.31857/s0044460x24050087
- Primary Topic
- Organophosphorus compounds synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00