Reaction of aroylpyruvic acids methyl esters with 4-aminobenzoic acid. Antioxidant activity of the obtained compounds
4-{[(2Z)-4-Aryl-2-hydroxy-4-oxobut-2-enoyl]amino}benzoic acids were synthesized by reacting methyl esters of aroylpyruvic acids with 4-aminobenzoic (p-aminobenzoic) acid in glacial acetic acid in the presence of anhydrous sodium acetate. 4-{[(2Z)-4-Aryl-1-methoxy-1,4-dioxobut-2-en-2-yl)]amino}benzoic acids were synthesized by reacting the above reagents in a mixture of glacial acetic acid–ethanol (1:1) without adding anhydrous sodium acetate. Structure of the obtained compounds was confirmed by 1H and 13C{1H} NMR and IR spectroscopy. The antioxidant activity of the synthesized compounds was studied.
Authors
- В. Л. Гейн (ORCID: https://orcid.org/0000-0002-8512-0399)
- K. V. Namyatova
- С. С. Зыкова (ORCID: https://orcid.org/0000-0002-7395-4951)
- O. V. Bobrovskaya (ORCID: https://orcid.org/0000-0002-3394-9031)
- D. V. Chalkov (ORCID: https://orcid.org/0009-0001-0367-3863)
Institutions
- Ministry of Health of the Russian Federation (RU)
- Perm State Pharmaceutical Academy (RU)
Publication Details
- Journal
- Журнал Общей Химии
- Published
- 2024-10-14
- DOI
- https://doi.org/10.31857/s0044460x24050011
- Primary Topic
- Biochemical and biochemical processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00