Reaction of aroylpyruvic acids methyl esters with 4-aminobenzoic acid. Antioxidant activity of the obtained compounds

4-{[(2Z)-4-Aryl-2-hydroxy-4-oxobut-2-enoyl]amino}benzoic acids were synthesized by reacting methyl esters of aroylpyruvic acids with 4-aminobenzoic (p-aminobenzoic) acid in glacial acetic acid in the presence of anhydrous sodium acetate. 4-{[(2Z)-4-Aryl-1-methoxy-1,4-dioxobut-2-en-2-yl)]amino}benzoic acids were synthesized by reacting the above reagents in a mixture of glacial acetic acid–ethanol (1:1) without adding anhydrous sodium acetate. Structure of the obtained compounds was confirmed by 1H and 13C{1H} NMR and IR spectroscopy. The antioxidant activity of the synthesized compounds was studied.

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Journal
Журнал Общей Химии
Published
2024-10-14
DOI
https://doi.org/10.31857/s0044460x24050011
Primary Topic
Biochemical and biochemical processes
Type
article
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article

Reaction of aroylpyruvic acids methyl esters with 4-aminobenzoic acid. Antioxidant activity of the obtained compounds

В. Л. Гейн, K. V. Namyatova, С. С. Зыкова, O. V. Bobrovskaya et al.
Журнал Общей Химии
Biochemical and biochemical processes
article

Reaction of aroylpyruvic acids methyl esters with 4-aminobenzoic acid. Antioxidant activity of the obtained compounds

В. Л. Гейн, K. V. Namyatova, С. С. Зыкова, O. V. Bobrovskaya, D. V. Chalkov
article en

Abstract

4-{[(2Z)-4-Aryl-2-hydroxy-4-oxobut-2-enoyl]amino}benzoic acids were synthesized by reacting methyl esters of aroylpyruvic acids with 4-aminobenzoic (p-aminobenzoic) acid in glacial acetic acid in the presence of anhydrous sodium acetate. 4-{[(2Z)-4-Aryl-1-methoxy-1,4-dioxobut-2-en-2-yl)]amino}benzoic acids were synthesized by reacting the above reagents in a mixture of glacial acetic acid–ethanol (1:1) without adding anhydrous sodium acetate. Structure of the obtained compounds was confirmed by 1H and 13C{1H} NMR and IR spectroscopy. The antioxidant activity of the synthesized compounds was studied.

Журнал Общей ХимииVol. 94(5)
Ministry of Health of the Russian Federation (RU), Perm State Pharmaceutical Academy (RU)
Clean water and sanitation, Life below water
Openalex Percentile: Top 76%
Biochemical and biochemical processes
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Reaction of aroylpyruvic acids methyl esters with 4-aminobenzoic acid. Antioxidant activity of the obtained compounds — В. Л. Гейн, K. V. Namyatova, et al. · Журнал Общей Химии (2024) | TGRS Research Map | TGRS