Pyrazolines and pyrimidines based on (<i>E</i>)-1-(4-pentyloxyphenyl)-3-arylprop-2-en-1-ones. Synthesis, docking study and luminescent properties
(E)-1-(4-Pentyloxyphenyl)-3-(aryl)prop-2-en-1-ones were obtained by condensation of 1-(4-pentyloxyphenyl)ethanone with aromatic aldehydes in an aqueous ethanol solution in the presence of NaOH. The corresponding pyrazoline derivatives were prepared by cyclization of substituted chalcones with phenylhydrazine in an acidic medium, while 2,4,6-triaryl-substituted pyrimidines were produced in the case of benzamidine hydrochloride in the KOH–ethanol. It was found that all synthesized pyrazoline derivatives exhibit pronounced luminescent properties. A docking study of the compounds was carried out against four types of receptors.
Authors
- H. А. Panosyan (ORCID: https://orcid.org/0000-0001-8311-6276)
- R. P. Mkhitaryan (ORCID: https://orcid.org/0009-0009-6277-2747)
- Artur A. Hambardzumyan (ORCID: https://orcid.org/0000-0001-9526-7768)
- A. S. Sargsyan (ORCID: https://orcid.org/0000-0001-7249-233X)
- G. S. Grigoryan (ORCID: https://orcid.org/0000-0002-0675-735X)
- Z. A. Hovasyan (ORCID: https://orcid.org/0000-0001-6698-7184)
- A. U. Isakhanyan (ORCID: https://orcid.org/0000-0002-1713-4908)
- M. Yu. Danghyan (ORCID: https://orcid.org/0000-0001-7703-1591)
- А. А. Harutyunyan (ORCID: https://orcid.org/0000-0003-0641-5453)
- Liana Gabrielyan (ORCID: https://orcid.org/0000-0002-9212-9682)
Institutions
- Yerevan State University (AM)
- Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry (AM)
- National Academy of Sciences of Armenia (AM)
Publication Details
- Journal
- Журнал Общей Химии
- Published
- 2024-10-14
- DOI
- https://doi.org/10.31857/s0044460x24050048
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00