Synthesis and biological activity of substituted 5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamides
A four-component solvent-free reaction of acetoacetic acid amide with dimedone, aromatic aldehydes and ammonium acetate leads to new substituted 5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamides. The structures of the products were proved using IR, 1H and 13C NMR spectroscopy, mass spectrometry and X-ray diffraction analysis. The synthesized compounds were tested for antimicrobial and antinociceptive activities.
Authors
- В. В. Новикова (ORCID: https://orcid.org/0000-0003-4475-4421)
- В. Л. Гейн (ORCID: https://orcid.org/0000-0002-8512-0399)
- Н. В. Носова (ORCID: https://orcid.org/0000-0001-6380-2543)
- Р. Р. Махмудов (ORCID: https://orcid.org/0000-0002-2326-3976)
- М. О. Starovoytova
- М. В. Дмитриев (ORCID: https://orcid.org/0000-0002-8817-0543)
Institutions
- Moscow Power Engineering Institute (RU)
- Ministry of Health of the Russian Federation (RU)
- Solikamsk State Pedagogical Institute (RU)
- Perm State Pharmaceutical Academy (RU)
- Federal Scientific Center for Medical and Preventive Health Risk Management Technologies (RU)
Publication Details
- Journal
- Журнал Общей Химии
- Published
- 2024-10-14
- DOI
- https://doi.org/10.31857/s0044460x24050032
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00