Inhibition of Sat1 alleviates myocardial ischemia-reperfusion injury through regulation of ferroptosis via MAPK/ERK pathway
In sum, this study demonstrated Sat1 expression was increased in MIRI, inhibition of Sat1 can alleviate MIRI by regulating ferroptosis via MAPK/ERK pathway, and Sat1 was negatively regulated by Sox2. These findings suggested that Sat1 may serve as a potential therapeutic target for the treatment of MIRI.
Authors
- Hongjin Chen (ORCID: https://orcid.org/0009-0002-1820-2244)
- Zhou Liu (ORCID: https://orcid.org/0000-0002-6773-1073)
- Siyuan Yang (ORCID: https://orcid.org/0000-0002-2636-9610)
- Sisi Pan (ORCID: https://orcid.org/0000-0001-8166-0008)
- Kaiyuan Chen (ORCID: https://orcid.org/0009-0007-7133-228X)
- Deqin Lu
- Yingnan Song
Institutions
- Guiyang Medical University (CN)
- Zunyi Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fphar.2024.1476718
- Citations
- 11
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.57