Peripapillary Retinal Nerve Fiber Layer (pRNFL) Thickness – A Novel Biomarker of Neurodegeneration in Late-Infantile CLN2 Disease
Patients with late-infantile CLN2 disease exhibit early onset progressive pRNFL loss regardless of outer retinal degeneration, highlighting the potential of pRNFL as an independent ocular biomarker for retinal pathology in late-infantile CLN2 disease.
Authors
- Christoph Schwering (ORCID: https://orcid.org/0000-0002-3716-1575)
- Simon Dulz (ORCID: https://orcid.org/0000-0002-6893-9714)
- Miriam Nickel (ORCID: https://orcid.org/0000-0002-1870-1142)
- Martin S. Spitzer (ORCID: https://orcid.org/0000-0002-4588-1767)
- Yevgeniya Atiskova (ORCID: https://orcid.org/0000-0003-1840-0478)
- Carsten Grohmann
- Eva Wibbeler (ORCID: https://orcid.org/0000-0001-7451-3616)
- Angela Schulz (ORCID: https://orcid.org/0000-0001-9156-4861)
- Nikolaos Gkalapis (ORCID: https://orcid.org/0000-0001-9576-7455)
Institutions
- Universität Hamburg (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Eye and Brain
- Published
- 2024-11-01
- DOI
- https://doi.org/10.2147/eb.s473408
- Citations
- 1
- Primary Topic
- Lysosomal Storage Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.33