“Quality over quantity:” smaller, targeted lesions optimize quality of life outcomes after MR-guided focused ultrasound thalamotomy for essential tremor
We found that smaller lesion size and higher extent to which the lesion is within the NTA hotspot predicted patients' change in QoL at last follow-up. Though long-term change in clinical rating scale for tremor (CRST) impacted QoL, neither intraoperative tremor suppression nor the patient's long-term perception of tremor suppression correlated with QoL. We provide an intraoperative threshold for accumulated dose volume (<0.06 cc), which along with the network-based hotspot in the NTA, may facilitate an easily scalable approach to help limit treatment to small, safe yet effective lesions that optimize change in QoL after MRgFUS.
Authors
- Pejman Ghanouni
- Jaimie M. Henderson (ORCID: https://orcid.org/0000-0002-3276-2267)
- David Arnold Purger (ORCID: https://orcid.org/0000-0003-4668-1174)
- Jennifer A. McNab (ORCID: https://orcid.org/0000-0002-1763-0792)
- Allan Wang (ORCID: https://orcid.org/0000-0002-6622-1610)
- Anjali Datta (ORCID: https://orcid.org/0000-0002-3283-2202)
- Vivek Buch (ORCID: https://orcid.org/0000-0003-1151-6128)
- Daniel Barbosa (ORCID: https://orcid.org/0000-0002-4364-854X)
- Lior Lev-Tov (ORCID: https://orcid.org/0000-0002-5116-254X)
- Casey H. Halpern (ORCID: https://orcid.org/0000-0003-3907-216X)
- Rachelle Bitton
- Yosefi Chodakiewitz
- Chelsea Li
Institutions
- Rambam Health Care Campus (IL)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fneur.2024.1450699
- Citations
- 3
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Focused Ultrasound Foundation