[ <sup>99m</sup> Tc]-PentixaTec SPECT/CT for Imaging of Chemokine Receptor 4 Expression After Myocardial Infarction
This is the first report of in vivo CXCR4 imaging after AMI using a <sup>99m</sup>Tc-labeled tracer. Increased CXCR4 expression was observed locally in the infarcted region and was related to a systemic inflammatory response in the reticuloendothelial system. This proof-of-concept investigation demonstrates the general feasibility of evaluating the inflammation-related CXCR4 expression in the myocardium after AMI using conventional scintigraphy or SPECT and might, thus, broaden its worldwide application in clinical practice.
Authors
- Philip Raake (ORCID: https://orcid.org/0000-0001-8365-674X)
- Ralph A. Bundschuh (ORCID: https://orcid.org/0000-0001-7291-9372)
- Maximilian Rieger
- Takahiro Higuchi (ORCID: https://orcid.org/0000-0001-9711-7835)
- Margret Schottelius (ORCID: https://orcid.org/0000-0002-1928-6913)
- Georgine Wienand
- Alessandro Liebich
- Malte Kircher (ORCID: https://orcid.org/0000-0003-4355-0881)
- Constantin Lapa (ORCID: https://orcid.org/0000-0001-7536-2207)
- Christian H. Pfob (ORCID: https://orcid.org/0000-0003-2989-5883)
- Stephan G. Nekolla (ORCID: https://orcid.org/0000-0002-8817-1482)
Institutions
- University of Augsburg (DE)
- University Hospital Augsburg (DE)
- Centre Hospitalier Universitaire Vaudois (CH)
- TUM Klinikum (DE)
- Universitätsklinikum Würzburg (DE)
Publication Details
- Journal
- Circulation Cardiovascular Imaging
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1161/circimaging.124.016992
- Citations
- 2
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.77