Polygenic Risk Scores and Extreme Coronary Artery Calcium Phenotypes (CAC=0 and CAC≥1000) in Adults ≥75 Years Old: The ARIC Study
Polygenic CHD risk is robustly associated with a lower prevalence of CAC=0 and a higher prevalence of CAC≥1000 in adults ≥75 years of age, beyond lifestyle and traditional risk factors. These results suggest a heritable contribution to distinct healthy and unhealthy arterial aging phenotypes that persist throughout the life course.
Authors
- Alexander C. Razavi (ORCID: https://orcid.org/0000-0002-3213-0876)
- Frances Wang (ORCID: https://orcid.org/0000-0003-4950-582X)
- Michael Joseph Blaha (ORCID: https://orcid.org/0000-0001-5138-9683)
- Ron Blankstein (ORCID: https://orcid.org/0000-0002-8393-6562)
- Nilanjan Chatterjee (ORCID: https://orcid.org/0000-0002-9060-008X)
- Zeina Dardari (ORCID: https://orcid.org/0000-0001-6026-3329)
- Yasuyuki Honda (ORCID: https://orcid.org/0000-0002-6710-9890)
- Candace M. Howard (ORCID: https://orcid.org/0000-0001-6537-3551)
- Ziqiao Wang (ORCID: https://orcid.org/0000-0003-3383-8670)
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
- Tanika N. Kelly (ORCID: https://orcid.org/0000-0002-7348-4451)
- Paul S. de Vries (ORCID: https://orcid.org/0000-0003-0964-0111)
- Bing Yu (ORCID: https://orcid.org/0000-0003-4818-1077)
- Martin Bødtker Mortensen (ORCID: https://orcid.org/0000-0003-2693-4154)
- Omar Dzaye (ORCID: https://orcid.org/0000-0001-9483-3510)
- Khurram Nasir (ORCID: https://orcid.org/0000-0001-5376-2269)
- Aaron R. Folsom (ORCID: https://orcid.org/0000-0003-2635-2699)
- Seamus P. Whelton (ORCID: https://orcid.org/0000-0001-5914-0735)
- Kunihiro Matsushita (ORCID: https://orcid.org/0000-0002-7179-718X)
- Lynne E. Wagenknecht (ORCID: https://orcid.org/0000-0002-9980-0889)
- Jin Jin (ORCID: https://orcid.org/0000-0001-8357-8585)
Institutions
- Tulane University (US)
- Brigham and Women's Hospital (US)
- Houston Methodist (US)
- University of Minnesota (US)
- Emory Healthcare (US)
- Johns Hopkins University (US)
- Emory University (US)
- Aarhus University Hospital (DK)
- University of Mississippi Medical Center (US)
- Wake Forest University (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Circulation Cardiovascular Imaging
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1161/circimaging.123.016377
- Citations
- 3
- Primary Topic
- Cardiovascular Health and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- American Heart Association
- Amgen
- Eli Lilly and Company
- Novo Nordisk
- National Institutes of Health