A new dammarane-type triterpenoid saponin from the leaves of sour jujube

A new dammarane-type triterpenoid saponin, suanzaoside A (<b>1</b>) along with one known analogue 3-<i>O</i>-[<i>α</i>-L-rhamnopyranosyl(1→2)-<i>α</i>-L-arabinopyranosyl-]-30-<i>O</i>-[<i>β</i>-D-glucopyranosyl-(1→2)-<i>β</i>-D-glucopyranosyl]-3<i>β</i>,25,30-trihydroxy-16-one-20<i>R</i>,24<i>R</i>-epoxydammarane (<b>2</b>), were isolated from the leaves of sour jujube. The structure of these isolated compounds was elucidated by HRESIMS, 1D and 2D NMR spectroscopy, and literature comparison. In addition, the anti-inflammatory activities were further tested in LPS-induced RAW264.7 macrophage.