Africanized honeybee venom (Apis mellifera) promotes human complement activation split products storm
These results show that AmV is a strong complement activator. This activation presents a mixed profile, with a predominance of AP activation. This suggests that complement split products can play important roles in the envenomation by Africanized honeybee, as they could induce diverse immunopathological events observed in patients and may also dictate patient clinical prognosis.
Authors
- Felipe Silva de França (ORCID: https://orcid.org/0000-0003-0329-5177)
- Thyago Bispo Leonel
- Ricardo de Oliveira Orsi (ORCID: https://orcid.org/0000-0001-8099-8277)
- Dayanne Carla Fernandes (ORCID: https://orcid.org/0000-0003-2037-1397)
- Denise V. Tambourgi (ORCID: https://orcid.org/0000-0003-1896-9074)
Institutions
- Instituto Butantan (BR)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (BR)
- Centro de Estudos e Pesquisas em Educação, Cultura e Ação Comunitária (BR)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fimmu.2024.1463471
- Primary Topic
- Healthcare and Venom Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico