A sex-dependent role of Kv1.3 channels from macrophages in metabolic syndrome
Altogether, our data suggest that by inhibiting macrophage infiltration, Kv1.3 blockers could contribute to disrupt the vicious cycle of inflammation and insulin resistance, offering a novel approach to prevent MetS, T2DM and its associated cardiovascular complications in females.
Authors
- José R. López‐López (ORCID: https://orcid.org/0000-0002-3870-421X)
- M. Teresa Pérez‐García (ORCID: https://orcid.org/0000-0001-8540-8117)
- Diego A. Peraza (ORCID: https://orcid.org/0000-0002-3913-8619)
- Sara Moreno‐Estar (ORCID: https://orcid.org/0000-0001-8047-2865)
- Pilar Cidad (ORCID: https://orcid.org/0000-0002-6338-7738)
- Esperanza Alonso
- Lucía Benito-Salamanca
Institutions
- Universidad de Valladolid (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Instituto de Biomedicina y Genética Molecular de Valladolid (ES)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fphys.2024.1487775
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejería de Educación, Junta de Castilla y León
- Agencia Estatal de Investigación