The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer’s mouse model
These data indicate that highly selective ERβ agonism can facilitate object recognition memory in both APOE3 homozygotes and APOE3/4 heterozygotes, but only reduce the magnitude of a drug-induced hot flash in APOE3 homozygotes, suggesting that APOE4 genotype may blunt the beneficial effects of ET on hot flashes. Collectively, these data suggest a potentially beneficial effect of selective ERβ agonism for memory and hot flashes in females with AD-like pathology, but that APOE genotype plays an important role in responsiveness.
Authors
- Jason York
- Miranda R. Schwabe (ORCID: https://orcid.org/0000-0002-1776-8820)
- Karyn M. Frick (ORCID: https://orcid.org/0000-0002-4237-0208)
- Aaron W. Fleischer (ORCID: https://orcid.org/0000-0002-4349-0009)
- Mary Jo LaDu (ORCID: https://orcid.org/0000-0003-2141-1450)
- William A. Donaldson (ORCID: https://orcid.org/0000-0002-0840-3731)
- Daniel S. Sem (ORCID: https://orcid.org/0000-0002-2108-6646)
- Rachel K Kuehn
- S. Chaudhury
Institutions
- Marquette University (US)
- Concordia University Wisconsin (US)
- University of Illinois Chicago (US)
- University of Wisconsin–Milwaukee (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fnagi.2024.1477045
- Citations
- 6
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.15
Funders
- University of Wisconsin-Milwaukee
- National Institutes of Health
- University of Illinois at Urbana-Champaign