Prospective Screening of Cancer Syndromes in Patients with Mesenchymal Tumors
We conclude that second-hit analyses can be used in standard of care to identify syndrome-related tumors. This approach can help distinguish true manifestations of tumor syndromes from unrelated germline findings and enhance the understanding of germline predisposition in soft tissue tumors. Prospective screening using germline whole genome sequencing should be considered when comprehensive somatic sequencing is introduced into clinical practice.
Authors
- Karin Wallander (ORCID: https://orcid.org/0000-0001-8166-9678)
- Cecilia Haglund (ORCID: https://orcid.org/0000-0001-5484-8945)
- Panagiotis Tsagozis (ORCID: https://orcid.org/0000-0002-6631-2053)
- Johan Lindberg (ORCID: https://orcid.org/0000-0003-3610-6774)
- Felix Haglund (ORCID: https://orcid.org/0000-0002-7015-3841)
- Robert Bränström (ORCID: https://orcid.org/0000-0001-6245-7223)
- Markus Mayrhofer (ORCID: https://orcid.org/0000-0003-3403-0083)
- Venkatesh Chellappa (ORCID: https://orcid.org/0000-0003-1431-6949)
- Anna Gellerbring (ORCID: https://orcid.org/0009-0002-4505-2173)
- Ingegerd Öfverholm (ORCID: https://orcid.org/0000-0002-6907-8004)
- Yingbo Lin (ORCID: https://orcid.org/0000-0001-7190-2261)
- Valtteri Wirta (ORCID: https://orcid.org/0000-0003-3811-5439)
- Julia Mondini
- John Hardingz
Institutions
- Linköping University (SE)
- Uppsala University (SE)
- Karolinska University Hospital (SE)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- Cancers
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3390/cancers16223816
- Citations
- 2
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Karolinska Institutet
- Cancerföreningen i Stockholm
- Science for Life Laboratory