Integrated analysis of single-cell and bulk transcriptome reveals hypoxia-induced immunosuppressive microenvironment to predict immunotherapy response in high-grade serous ovarian cancer
Our study revealed hypoxia-induced immunosuppressive microenvironment, and developed Hypoxia-TME classifier to distinguish the prognosis, immune characteristics, and potential benefits of immunotherapy in HGSOC.
Authors
- Liqun Chi (ORCID: https://orcid.org/0000-0003-0605-4571)
- Hui Ding (ORCID: https://orcid.org/0000-0002-7568-182X)
- Qingshan Chen (ORCID: https://orcid.org/0000-0002-3714-9066)
- Yue Zhang (ORCID: https://orcid.org/0000-0001-7096-5463)
- Chao Wang (ORCID: https://orcid.org/0000-0002-8054-3472)
Institutions
- Hainan Maternal and Child Health Hospital (CN)
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.3389/fphar.2024.1450751
- Citations
- 3
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.86