Thorase deficiency causes both Aβ accumulation and tau hyperphosphorylation in mouse brain
Thorase deletion leads to elevated amyloid beta (Aβ) deposition and hyperphosphorylated tau accumulation in the brain. Thorase regulates the phosphorylation of tau protein via PP2B. Thorase deficiency impairs microglial phagocytosis and promotesNLRP3-mediated neuroinflammation. Overexpression of Thorase alleviates Aβ deposition and tau phosphorylation in the AD mouse model.
Authors
- Jingyi Han (ORCID: https://orcid.org/0000-0002-3765-2788)
- Menghua Cai
- Hui Chen (ORCID: https://orcid.org/0000-0003-2866-7811)
- Yu Hu (ORCID: https://orcid.org/0000-0002-9511-9383)
- Fei Gao (ORCID: https://orcid.org/0000-0002-3064-1461)
- Chao Li (ORCID: https://orcid.org/0000-0002-1305-9023)
- Jianmin Zhang (ORCID: https://orcid.org/0000-0003-4765-0812)
- Yi Xu (ORCID: https://orcid.org/0000-0002-1508-5081)
- Jia Ying Yang (ORCID: https://orcid.org/0000-0002-3992-4070)
- Wei He (ORCID: https://orcid.org/0000-0002-9509-6863)
- Han Zhang (ORCID: https://orcid.org/0009-0004-2828-3804)
- Yue Wang (ORCID: https://orcid.org/0000-0002-7496-8888)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1002/alz.14329
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.33
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- National Key Research and Development Program of China
- Chinese Academy of Medical Sciences Initiative for Innovative Medicine
- Institute of Basic Medical Sciences