Essential role of germ cell glycerol-3-phosphate phosphatase for sperm health, oxidative stress control and male fertility in mice
Germ cell G3PP deletion leads to the generation of spermatozoa that are functionally and structurally abnormal, likely due to the build-up of Gro3P that increases mitochondrial membrane potential, ROS, and oxidative stress and alters spermatozoa function. Overall, the results indicate that G3PP and the glycerol shunt are essential for normal spermatozoa function and male fertility.
Authors
- Derek Boerboom
- Carlos Ramón Morales (ORCID: https://orcid.org/0000-0002-4882-870X)
- Cristián O’Flaherty (ORCID: https://orcid.org/0000-0001-8884-1274)
- Marilène Paquet (ORCID: https://orcid.org/0000-0002-3562-4636)
- Hugh J. Clarke (ORCID: https://orcid.org/0000-0003-2626-244X)
- Anindya Ghosh (ORCID: https://orcid.org/0000-0002-8432-5288)
- Abel Oppong (ORCID: https://orcid.org/0000-0002-8006-1537)
- Alexandre Boyer (ORCID: https://orcid.org/0000-0001-7539-0056)
- Marc Prentki (ORCID: https://orcid.org/0000-0002-0499-3324)
- Fahd Al‐Mulla (ORCID: https://orcid.org/0000-0001-5409-3829)
- Yat Hei Leung
- S.R. Murthy Madiraju (ORCID: https://orcid.org/0000-0002-2613-2074)
- Marie‐Line Peyot
Institutions
- McGill University Health Centre (CA)
- Cegep de Saint Hyacinthe (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Dasman Diabetes Institute (KW)
- McGill University (CA)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1016/j.molmet.2024.102063
- Citations
- 11
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 5.91
Funders
- Dasman Diabetes Institute
- Canadian Institutes of Health Research