The expression of contextual fear conditioning involves the dorsal hippocampus TRPV1 receptor interacting with the NMDA/NO/cGMP signalling pathway
Our study revealed that TRPV1 receptors in the dHIP play a crucial role in modulating contextual fear expression by acting through the NMDA receptor/NO/cGMP signalling pathway, providing important insights into the underlying mechanisms and potential therapeutic avenues associated with these pathways.
Authors
- Leonardo B.M. Resstel (ORCID: https://orcid.org/0000-0001-5439-7793)
- Sabrina F. Lisboa (ORCID: https://orcid.org/0000-0002-2069-3524)
- Andreza Buzolin Sonego (ORCID: https://orcid.org/0000-0002-1014-5380)
- Gabriela Luiz Bertacchini
- Davi C. Lagatta (ORCID: https://orcid.org/0000-0002-2944-4559)
Institutions
- Universidade Federal de Mato Grosso do Sul (BR)
- Universidade de São Paulo (BR)
- Universidade Estadual de Mato Grosso do Sul (BR)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-11-12
- DOI
- https://doi.org/10.1111/bph.17384
- Citations
- 3
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo