Enhanced immune responses are accompanied by increased MAGEA expression in osteosarcoma metastases
These findings indicate a concurrent augmentation of cytotoxic antitumour immune responses and expression of MAGEA antigens from primary to metastatic osteosarcoma. This observation suggests the exploration of MAGEA antigens as potential targets for immunotherapy in the treatment of advanced osteosarcoma.
Authors
- Marieke E. Ijsselsteijn (ORCID: https://orcid.org/0000-0002-8195-736X)
- Manon van der Ploeg (ORCID: https://orcid.org/0000-0001-7150-3068)
- Pauline M. Wijers‐Koster (ORCID: https://orcid.org/0009-0002-4758-7016)
- Stéphanie Lam (ORCID: https://orcid.org/0000-0003-1698-1061)
- Peter A. van Veelen (ORCID: https://orcid.org/0000-0002-7898-9408)
- Debora M. Meijer (ORCID: https://orcid.org/0000-0002-6399-3084)
- Arnoud H. de Ru (ORCID: https://orcid.org/0009-0002-1166-4059)
- Hans A. J. Gelderblom (ORCID: https://orcid.org/0000-0001-9270-8636)
- Michiel A. J. van de Sande (ORCID: https://orcid.org/0000-0002-9156-7656)
- Brendy E. van den Akker
- Siddh van Oost (ORCID: https://orcid.org/0000-0003-2281-5780)
- Dina Ruano (ORCID: https://orcid.org/0000-0002-8231-3398)
- Alwine B. Kruisselbrink (ORCID: https://orcid.org/0000-0002-9778-4432)
- Noel F.C.C. de Miranda (ORCID: https://orcid.org/0000-0001-6122-1024)
- Jessica Roelands (ORCID: https://orcid.org/0000-0003-3631-2041)
- Inge H. Briaire‐de Bruijn (ORCID: https://orcid.org/0000-0002-9273-2828)
- Rayman T.N. Tjokrodirijo (ORCID: https://orcid.org/0009-0007-4878-8385)
- Marieke L. Kuijjer (ORCID: https://orcid.org/0000-0001-6280-3130)
- Judith V.M.G. Bovée (ORCID: https://orcid.org/0000-0003-1155-0481)
Institutions
- University of Oslo (NO)
- Leiden University Medical Center (NL)
- Netherlands Metabolomics Centre (NL)
Publication Details
- Journal
- BMJ Oncology
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1136/bmjonc-2024-000472
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- ZonMw
- Leids Universitair Medisch Centrum
- H2020 European Research Council