Meningiomas: Sex-specific differences and prognostic implications of a chromosome X loss
Although genomic instability is a common feature of malignant meningiomas, particularly loss of the X chromosome in tumors of female patients in otherwise histologically and molecularly low-risk tumors confers higher risk. Hence, the gonosomal copy-number status can be leveraged for increased diagnostic accuracy.
Authors
- Sybren L. N. Maas (ORCID: https://orcid.org/0000-0002-8745-4405)
- Till Acker (ORCID: https://orcid.org/0000-0001-6357-7227)
- Michael Weller (ORCID: https://orcid.org/0000-0002-1748-174X)
- Christel C. Herold‐Mende (ORCID: https://orcid.org/0000-0002-1915-745X)
- Daniel Schrimpf (ORCID: https://orcid.org/0000-0003-3063-2423)
- Andreas von Deimling (ORCID: https://orcid.org/0000-0002-5863-540X)
- Matthias Preusser (ORCID: https://orcid.org/0000-0003-3541-2315)
- Felix Sahm (ORCID: https://orcid.org/0000-0001-5441-1962)
- Natalie Berghaus (ORCID: https://orcid.org/0000-0002-5791-698X)
- Wolfgang Wick (ORCID: https://orcid.org/0000-0002-6171-634X)
- D. Savran (ORCID: https://orcid.org/0000-0002-2685-5600)
- Thomas Hielscher (ORCID: https://orcid.org/0000-0003-1277-310X)
Institutions
- German Cancer Research Center (DE)
- Justus-Liebig-Universität Gießen (DE)
- University of Zurich (CH)
- Heidelberg University (DE)
- Leiden University Medical Center (NL)
- University Hospital Heidelberg (DE)
- University Hospital of Zurich (CH)
- National Center for Tumor Diseases (DE)
- Erasmus MC Cancer Institute (NL)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2024-11-13
- DOI
- https://doi.org/10.1093/neuonc/noae239
- Citations
- 6
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 2.32