Comprehensive analysis of molecular mechanisms underlying kidney stones: gene expression profiles and potential diagnostic markers

The study comprehensively analyzed gene expression profiles to uncover molecular mechanisms underlying kidney stones. KLK1 and MMP10 were identified as potential diagnostic markers and key players in kidney stone progression. Functional enrichment analysis provided insights into their roles in metabolic processes, immune response, and disease pathology. These results contribute significantly to a better understanding of kidney stone pathogenesis and may inform future diagnostic and therapeutic strategies.

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Publication Details

Journal
Frontiers in Genetics
Published
2024-11-13
DOI
https://doi.org/10.3389/fgene.2024.1440774
Citations
3
Primary Topic
Kidney Stones and Urolithiasis Treatments
Type
article
Field-Weighted Citation Impact
1.26

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article

Comprehensive analysis of molecular mechanisms underlying kidney stones: gene expression profiles and potential diagnostic markers

Aji Kunnath Devadas, Gwonhwa Song, Asimujiang Abula, Aierken Aikebaier
3 citations
Frontiers in Genetics
Kidney Stones and Urolithiasis Treatments
1.26
article

Comprehensive analysis of molecular mechanisms underlying kidney stones: gene expression profiles and potential diagnostic markers

Aji Kunnath Devadas, Gwonhwa Song, Asimujiang Abula, Aierken Aikebaier
article en
3 citations

Abstract

The study comprehensively analyzed gene expression profiles to uncover molecular mechanisms underlying kidney stones. KLK1 and MMP10 were identified as potential diagnostic markers and key players in kidney stone progression. Functional enrichment analysis provided insights into their roles in metabolic processes, immune response, and disease pathology. These results contribute significantly to a better understanding of kidney stone pathogenesis and may inform future diagnostic and therapeutic strategies.

Frontiers in GeneticsVol. 15
Xinjiang Medical University (CN), First Affiliated Hospital of Xinjiang Medical University (CN)
Natural Science Foundation of Xinjiang
Good health and well-being
Openalex Percentile: Top 18%
Kidney Stones and Urolithiasis Treatments
1.26
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